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The extracellular Cys/CySS (cysteine/cystine) redox couple represents the principal determinant of cysteine supply to cells [56]: extracellular cystine is imported via the system X c − transporter, reduced intracellularly to cysteine, and channeled into GSH synthesis — making cystine import, rather than glutamate availability, the rate-limiting step for GSH production in most cell types [57]
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