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Conversely, decreased Cav-1 level or obstructed Cav-1 and eNOS interaction can release eNOS favoring its activation and induction of nitric oxide production that is known for its protective effect on vessels 44,45
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To improve the anti-tumor efficacy of the vaccine, strategies based on the following four perspectives may be able to effectively reverse the suppressive TME: (Karankar et al., 2025)
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