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Aerobic exercise, a condition known to prevents renal disease progression in CKD models,132 has been linked to elevated plasma IGF-1 levels, which may partially contribute to the improved renal outcomes.133 Moreover, IGF-1 plays a significant role in the development of CKD-associated sarcopenia
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Since the discovery of ghrelin, an endogenous ligand for GHS-R (44), and the observation that this peptide is expressed in oxyntic mucosal cells (A/X cells) of empty stomach and sharply rises before meal, while falling within one hour after a meal (44-46), a great attention has been paid regarding the possible role of this peptide in stimulating food intake ( Fig
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