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NDGA showed ameliorating potential on inflammatory bone destruction mediated by osteoclasts via the inhibition of calcium oscillation followed by the downregulation of a key transcription factor for osteoclastogenesis NFATc1 and inhibition of RANKL-induced osteoclastogenesis in cultures of murine osteoclast precursor cell line RAW-D and primary bone marrow-derived macrophages [185]
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