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doi: 10.1016/j.neuint.2007.08.018

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It was found that bilirubin had a lower kinetic binding to MRGPRA1 than PPARα, with an EC 50 = 145.9 μM for MRGPRA1 excitation quantitated in MRGPRA1-overexpressing cells challenged with bilirubin to generate an intracellular calcium signaling response [34]

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