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Betaine can significantly increase the activity of antioxidant enzymes [SOD and glutathione peroxidase (GPx)], restore GSH levels, reduce MDA content, inhibit the expression of primary inflammatory factors (NF-κB, TNF- α , and COX-2), and inhibit lipid deposition and degeneration (124–131) (Figure 5D)

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Reporting shows that more than $83 million in federal research funding was canceled and around 383 NIH-funded clinical trials lost support within six months, exposing how vulnerable clinical timelines are to political and budgetary decisions beyond the protocol