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Proline-rich sequences broaden on reverse-phase HPLC because the bond preceding each proline interconverts between cis and trans conformations slowly relative to the run, so a broad or shouldered peak is a property of the molecule rather than evidence of a second substance
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Future directions for addressing female underrepresentation and improving NSTE-ACS management Existing studies highlight the ongoing issue of underrepresentation of females in clinical trials, with an average participation rate of ~25%, which leads to their underdiagnosis and undertreatment
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