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Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)
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Among these states, one exhibited a neural crest stem cell (NCSC) transcriptional programme largely driven by the nuclear retinoid acid receptor RXRG
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