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Moreover, 2-mercaptoethanol can reduce extracellular cystine to cysteine, which is then transported into the cell through the L system, thereby skipping the system xc - and support GSH synthesis [96]

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Glossary OSF Oral submucosal fibrosis AN Areca Nut WHO World Health Organization OSCC Oral Squamous Cell Carcinoma HPV Human Papilloma Virus EMT Epithelial-Mesenchymal Transition NGS Next-Generation Sequencing IARC International Agency for Research on Cancer CMI Chronic Mechanical Irritation ANA Anti-Nuclear Antibodies SMA Smooth Muscle Actin GPCA Anti-Gastric Parietal Cell Hb Hemoglobin LOX Lysyl Oxidase HLA Human Leukocyte Antigen CTLA-4 Cytotoxic T Lymphocyte-Associated Antigen-4 GST Glutathione S-Transferase MMPs Matrix Metalloproteinase ROS Reactive Oxygen Species NO Nitric oxide MFBs Myofibroblasts TIMPs Tissue Inhibitors of Metalloproteinases HIF-1α Hypoxia-Inducible Factor-1a VEGF Vascular Endothelial Growth Factor TNF-α Tumor Necrosis Factor-alpha IHC Immunohistochemical PCNA Proliferating Cell Nuclear Antigen CYPA Cyclophilin A MALDI-IMS Matrix-Assisted Laser Desorption Imaging Mass Spectrometry NCOA7 Nuclear Receptor Coactivator 7 E-SOD Erythrocyte Superoxide Dismutase GPx Glutathione Peroxidase LDH Lactate Dehydrogenase MDA Malondialdehyde 8-OHdG 8-hydroxy-2-deoxyguanosine OCT Optical Coherence Tomography FTIR Fourier Transform Infrared Spectroscopy NADH Nicotinamide Adenine Dinucleotide TGF-β1 Transforming Growth Factor-beta 1 HBOT Hyperbaric Oxygen Therapy TCM Traditional Chinese Medicine EGCG Epigallocatechin-3-gallate TGM-2 transglutaminase-2 PRP Platelet-Rich Plasma References 1 AdtaniP