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doi: 10.1016/j.lfs.2016.10.012

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Therefore, given the important relationship between oxidative stress and the progression of CKD, therapeutic strategies aimed at mitigating oxidative stress, reducing inflammation, and improving renal function have been implemented, such as xanthine oxidase inhibitors (such as allopurinol and febuxostat), dietary antioxidants (such as vitamins C and E, coenzyme Q10, resveratrol, and curcumin), NADPH oxidase inhibitors (e.g., GKT137831 and APX-115), and Nrf2 activators (such as bardoxolone methyl) [22,27,28,29,30,31,32,33,34,35,36]