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SGLT-2 inhibition confers notable reno-protective effects, not only mitigating glomerular hyperfiltration but also reducing intraglomerular pressure through vasodilation of the efferent glomerular arterioles and vasoconstriction of the afferent arterioles (5)
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This impairs the uptake of cystine by tumor cells, leading to increased lipid peroxidation and ferroptosis
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