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IRS-1 acts as a critical crosstalk mediator between IGF-1R and FGFR1 pathways, encompassing a feedback loop between IRS-1 and MAPK/ERK ( 6.4.2 Deleterious interactions with other growth factors Further supporting the complexity of crosstalk between IGF-1R and other tyrosine kinase receptor pathways, unclear synergistic actions of EGF, PDGF, TGF-β, and IGF induce stemness, cancer progression and metastasis, drug resistance, and tumor relapse in various cancer types ( via IGF-1R reactivated MAPK signaling to mediate cancer cell drug resistance, highlighting the concomitant targeting of MEK and IGF-1R/MAPK signaling pathways as a potential therapeutic strategy in high-risk neuroblastoma

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Quantity:30 capsules

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