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Pyruvate is then broken down to form acetyl-coA by pyruvate dehydrogenase (PDH)
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This seems to be particularly common in the neurotoxicology literature and in toxicology reports (see review by Ek et al., Functional Significance of Early Development of Brain Barriers Without the diffusion restraint provided by intercellular junctions in brain barrier interfaces it would not be possible to establish efflux or influx mechanisms such as those controlling ionic gradients between blood and cerebrospinal fluid (CSF
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