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H3 receptors: The central and peripheral nervous systems contain H3 receptors, which act as a feedback loop for histamine levels in the brain
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Consistent with this context-dependent framework, lifestyle factors further contribute to metabolic heterogeneity in PCOS, as dietary patterns characterized by higher fat intake, greater consumption of medium/high glycemic index foods, and lower physical activity have been associated with increased insulin resistance and inflammation, whereas higher fiber intake shows protective associations with metabolic markers [123]
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