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In summary, as an enzyme cofactor, ASC participates in abiotic stress responses by modifying plant cell composition, coordinating phytohormone biosynthesis, and regulating gene expression via epigenetic pathways (Figure 2)
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This leads to decreased peripheral and central 5-HT levels, impaired receptor function, reduced concentrations of tryptophan and 5-HT (232), worsened symptoms of affective disorders, elevated levels of tryptophan catabolites (233, 234), and increased concentrations of toxic metabolites in the CNS (235)
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