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In the metabolism of aromatic amines, N-hydroxy aromatic amine metabolites generated in the liver enter the bladder via urine and are further acetylated by NAT1 in the bladder epithelial cells, resulting in the production of highly reactive intermediates
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Cell death analysis Cells (5 × 10 5 cells/well) were seeded in 6-well plates and cultured in control condition and exposed to 0.4 mM L-cysteine and/or hypoxia induced with 0.1 mM cobalt chloride
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