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In colorectal cancer (CRC), uridine-cytidine kinase-like 1 (UCKL1) knockdown induces ferroptosis in both in vitro and in vivo models by destabilizing NRF2 and reducing GPX4, FSP1, and SLC7A11 expression, independent of its role in pyrimidine metabolism [102]
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485 Additionally, overexpressing ABCB8, a mitochondrial protein that promotes iron export, reduces both mitochondrial ROS and iron, improving DOX-induced cardiomyopathy
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