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269 achieved optical control of protein activity for firefly luciferase, BRAF kinase, KRAS GTPase, and MEK1 kinase by genetically incorporation of photocaged aspartic acid ONBD and MeONBD via newly evolved PylRS mutants to replace functionally essential Asp residues in these proteins
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A specific conformational change may be required for full-length receptor signaling J Biol Chem 1998 273 : 5307–5314
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