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The mechanism: KPV translocates into the cell nucleus and blocks the interaction between importin-alpha3 and the p65/RelA subunit of NF-kB, preventing p65 from reaching its transcriptional targets
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Eastman et al., 2020), i.e., in acute brain damage, such as stroke and epilepsy, the brain tissue is particularly vulnerable to oxidative stress due to consumption of a large amount of oxygen and produces a large number of free radicals as compared to other tissues
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