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[5], [6], [7] Transcription factors of the FOXO family – specifically FOXO1, FOXO3, FOXO4, and FOXO6 – are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes

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In the placebo subjects, the observed decrease was only 5.1 and 20.5%, respectively