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To avoid diluting the results with low-specificity phenotypes, we then excluded endpoints containing any of the (case-insensitive) keywords ‘other’ (for example, ‘Other disorders of ear’), ‘unspecified’ (for example, ‘Disorder of external ear, unspecified’), classified (for example, ‘Other viral diseases, not elsewhere classified’), ‘any’ (for example, ‘Any mental disorder’) or ‘all’ (for example, ‘All kidney diseases’), as well as derived endpoints for which the listed category did not correspond to a chapter of the ICD