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Injection may be perceived as more potent or biologically effective, but it substantially changes the risk profile by introducing concerns about sterility, reconstitution technique, dosing accuracy, injection-site infection, abscess formation, needle safety, and systemic exposure [12,17]

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[71] Quality of life is worsened by the extent of chronic pain, visible disfigurement, functional impairment, cognitive impairment, and psychiatric manifestations including anxiety and depression