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ALDH2 rs671 polymorphism may expedite the onset and progression of cardiovascular diseases by modulating biological processes such as autophagy, apoptosis, and oxidative stress in cardiomyocytes and VSMCs through ROS-mediated lipid peroxidation (99)
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GSH supplements would seem to be the most efficient way to increase cellular levels of GSH because if significant amounts of GSH are absorbed intact and are biologically active and also if the digestion process breaks down additional amounts of the supplemental GSH into its precursors—which would then be also absorbed and available for recombination into GSH—the inter- and intracellular GSH transport mechanisms would be shifted in favor of increased cellular GSH
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