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The H2S-dependent BP-reducing effect is thought to be primarily mediated through sulfhydration of ATP-sensitive potassium (KATP) channels, which in turn leads to voltage-sensitive channel opening and relaxation of vascular smooth muscle cells

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At the systemic level, IR refers to a reduction in systemic insulin sensitivity, which can be assessed using measures such as the oral glucose tolerance test (OGTT) and the insulin tolerance test (ITT)