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This was confirmed to me by my business partner and genius biochemist Nick Andrews, who had the following to say: “Chronic administration has been tested and shown to not generate toxic or negative effects while generating the positive effects observed in adipose tissue as well as muscle tissue.” My best guess is that this is supported by what has been seen in animal and cell models thus far: “5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid

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They range from consuming high levels of exogenous histamine either from the environment or from consuming high histamine containing foods, changes in an individual’s gut microflora population, leaky gut syndrome, GI bleeding, mastocytosis and the overuse of prescribed antibiotics without probiotics to counteract the effects