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Around 20 % of the glycolytic pathway is fluxed via the Rapoport-Luebering shuttle, thus bypassing the direct conversion of 1,3-PBG to 3-phosphoglycerate, which would, under normal conditions, yield ATP, as mediated by phosphoglycerate kinase (Reference Rapoport and Luebering47,Reference Duhm, Deuticke and Gerlach48)
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The authors describe several clinical studies conducted with selenium as the primary intervention
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