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Deficiencies of macroautophagy may contribute to accumulation of protein aggregates, which are apparent in a number of neurodegenerative diseases, including Alexander disease, multiple system atrophy, amyloid lateral sclerosis, Alzheimer's, Parkinson's, and Huntington's diseases
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Additionally, intriguing connections with genes like mitoferrin 2 hint at potentially specific pathogenic issues that remain incompletely understood
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