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Cardioprotective effect of antioxidant combination therapy: A highlight on MitoQ plus alpha-lipoic acid beneficial impact on myocardial ischemia-reperfusion injury in aged rats - ScienceDirect

COPD has long been assessed primarily based on symptoms, lung function, and exacerbation risk, but these indicators are insufficient to reflect the dominant pathological processes underlying the disease in individual patients (256)

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Although the effector (ligand) molecule at higher doses can nonspecifically interact with numerous molecules of several networks, this may cause both feedback downregulations and antagonistic interactions of various molecular networks, resulting in quite different pharmacological responses and toxic effects