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198,677 Notable, 12(13)-EpOME was shown to increase mitochondrial non-ADP-stimulated and oligomycin-insensitive (i.e., state 4) respiration and reduce succinate-dependent and oligomycin-sensitive (i.e., state 3) respiration in isolated rabbit renal cortical mitochondria (at relatively high concentrations of 50 mM)
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This set of phenotypes is reminiscent of what has been observed in flies under dietary restriction (DR) 27
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