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The mechanism by which this occurs is by restoring the control conditions of different pathways leading to peripheral sensory neuropathy ( Ex vivo analyses showed that probiotics reduced colon tissue damage, upregulated the levels of cannabinoid and opioid expression in the spinal cord, reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 and peroxisome proliferator-activated receptor γ (PPAR γ) and reduced serum levels of TNF-α, IL-1 and IL-6 when compared to PCTX treatment (Cuozzo et al., 2021)
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Microvascular pathology has also been delineated in the Dementias, and contributes to perpetual, pathologic cycles
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