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Best et al similarly reported positive effects of RT on white matter structure, demonstrating a reduced rate of white matter atrophy in individuals in the RT group compared to controls after the 1-year training intervention as well as 1 year post-intervention ( Effects of resistance exercise training on cognitive function The effects of acute and habitual exercise of any type on cognitive function are well established, with multiple quality reviews highlighting the effectiveness of resistance exercise on improved cognition across multiple domains (Landrigan et al., 2020

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By using a permutation test of 400-times, the quality of OPLS-DA model was validated, where R 2 Y represents the degree of fit between the model and the data, and Q 2 indicates how strong the predictive power of the model is, with a Q 2 greater than 0.5 considered “good” and a Q 2 greater than 0.9 deemed “excellent”