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However, this function can be compromised during copper overload, as Cu²⁺ binding to the cysteine residues of GPX4 promotes its ubiquitination and autophagic degradation, thereby disrupting lipid peroxide metabolism and sensitizing cells to ferroptosis [65]

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Figure 2 4.2 Synaptic plasticity and neurotransmission PSD-95, a protein in neurons with a PDZ domain, has been observed to promote the maturation of glutamatergic synapses in hippocampal neurons when its expression is increased (73), DHA promotes the expression of PSD-95 protein in the postsynaptic dense region and stabilizes glutamate receptors (such as NMDA receptors) (74)

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