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Reduces depression: A randomized, double-blind crossover trial showed that 100 mg of vitamin B6 daily for 4 weeks decreased depression scores in young women who use oral contraceptives (which decrease B6).[ref] A 2026 clinical trial showed that B6 supplementation (pyridoxine) reduced depression scale scores only in depressed individuals, with no effect on mood for people who weren’t depressed.[ref] High homocysteine: Numerous studies show that high homocysteine levels may respond to supplemental vitamin B6 (usually along with folate and B12)