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Despite the methodology used to study neutrophil function, other parameters, such as patient characteristics, cirrhosis aetiology and severity, presence of previous or active bacterial infections, active alcohol drinking, neutrophil isolation technique (given the ex vivo fragility of neutrophils), and the combination of all these factors can contribute to the discrepancies in results between studies (Table S1)
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Overall, the data show that actin networks and cytoskeletal activity inhibit mitoxyperiosis by controlling contact between the mitochondria and plasma membrane
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