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Development of novel therapeutics targeting mitochondrial metabolism In recent years, an increasing number of mitochondria-targeted therapeutic candidates have entered preclinical development or clinical evaluation, showing promising anti-CRC potential [146] (Table 1)
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The variable R group gives rise to the four most commonly known cobalamins: cyanocobalamin (CNCbl), methylcobalamin (MeCbl), adenosylcobalamin (AdCbl, also known as cobamamide or 5-deoxyadenosylcobalamin), and hydroxocobalamin (OHCbl)
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