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Tanycytes have also been involved in obesity-associated leptin resistance and, in the median eminence, form a diet-responsive neurogenic niche for newborn neurons that express LepRb and can integrate the functional circuit later in their life 58

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The Risérus 2001 trial in metabolic syndrome men showed CLA produced significant reductions in sagittal abdominal diameter, suggesting visceral-fat-preferential effects (Risérus 2001)