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Cysteine is catabolized by several desulfuration reactions that release sulfur in a reduced oxidation state, generating sulfane sulfur or hydrogen sulfide (H 2 S), which can be further oxidized to sulfate
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Inhibition of autophagy through bafilomycin treatment or ATG5 knockdown prevents Trx1 degradation, indicating AMPK-dependent autophagy mediates Trx1 degradation (136)
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