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In addition, Kim and colleagues’ study [287] revealed that MMP-9 is an epigenetic regulator—it enters the nuclear compartment where it cleaves the histone H3 N-terminal tail (H3NT), promoting osteoclastogenic gene activation (CTSK also may play a role as an epigenetic regulator of osteoclast gene expression [284])
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They describe those distinct study designs rather than recommending use of the listed material, which is not intended for humans or animals
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