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Spatiotemporal immunomodulation with programmable biomaterials to promote musculoskeletal tissue regeneration - ScienceDirect

doi: 10.1038/nchembio.2238 146 HuQZhangYLouHOuZLiuJDuanWet al

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Disturbed mitochondrial dynamics includes abnormal and/or impaired fission/fusion that occurs in response to nutrient excess and cellular dysfunction, directly impacts mitochondrial function, resulting in an excessive generation of ROS, altered mitochondrial enzymatic activities, impaired calcium homeostasis, diminished ATP production, and overall reduced energy metabolism in mammalian cells