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Extracellular Matrix Remodeling Studies investigating AHK-Cu’s effects on tissue architecture have documented: Modulation of tissue inhibitors of metalloproteinases (TIMPs) Balance between matrix synthesis and degradation pathways Influence on collagen cross-linking enzyme activity Effects on dermal thickness measurements in laboratory models [CALLOUT BOX – Highlighted] Critical Research Limitation: The vast majority of AHK-Cu research consists of in vitro cell culture studies and ex vivo tissue experiments