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While direct evidence for density-dependent inter-organ macrophage communication remains lacking, these shared regulatory principles raise the possibility that gut and brain barrier macrophages may participate in coordinated responses through common systemic signalling pathways

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475 Intriguingly, a recent study has further shown that the commensal bacterium Lactobacillus salivarius HHuMin-U restricts norovirus infection by modulating host TBK1-IRF3 and NF-κB signaling pathways