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The antioxidant system involved in the defense against ferroptosis is mainly controlled by the transcription factor nuclear factor erythroid-2-related factor (NRF2), which is known to induce the expression of antioxidant enzymes and lipid detoxification enzymes [46]
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Circulating metabolite biomarkers often suffer from limited specificity, tissue biopsies may miss intratumoral metabolic heterogeneity and the dense stromal matrix continues to hinder effective drug delivery
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